Article
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.
Molecular and cellular neurosciences - 1 Jan 2003
Brandon Nicholas J, Jovanovic Jasmina N, Colledge Marcie, Kittler Josef T, Brandon Julia M, Scott John D, Moss Stephen J
Abstract excerpt
GABA(A) receptors, the key mediators of fast synaptic inhibition in the brain, are predominantly constructed from alpha(1-6), beta(1-3), gamma(1-3), and delta subunit classes. Phosphorylation by cAMP-dependent protein kinase (PKA) differentially regulates receptor function dependent upon beta subunit identity, but how this kinase is selectively targeted to GABA(A) receptor subtypes remains unresolved. Here we...
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