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Article

HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects.

PloS one - 1 Jan 2012

Medrano Luz María, Dema Bárbara, López-Larios Arturo, Maluenda Carlos, Bodas Andrés, López-Palacios Natalia, Figueredo M Ángeles, Fernández-Arquero Miguel, Núñez Concepción

Abstract excerpt

Celiac disease (CD) is a chronic inflammatory disorder triggered after gluten ingestion in genetically susceptible individuals. The major genetic determinants are HLA-DQA1*05 and HLA-DQB1*02, which encode the DQ2 heterodimer. These alleles are commonly inherited in cis with DRB1*03∶01, which is associated with numerous immune-related disorders, in some cases contributing with a different amount of risk depending...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23119005
DOI: 10.1371/journal.pone.0048403
PMCID: PMC3485232

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TNF

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