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Article

Improving the estimation of celiac disease sibling risk by non-HLA genes.

PloS one - 1 Jan 2011

Izzo Valentina, Pinelli Michele, Tinto Nadia, Esposito Maria Valeria, Cola Arturo, Sperandeo Maria Pia, Tucci Francesca, Cocozza Sergio, Greco Luigi, Sacchetti Lucia

Abstract excerpt

Celiac Disease (CD) is a polygenic trait, and HLA genes explain less than half of the genetic variation. Through large GWAs more than 40 associated non-HLA genes were identified, but they give a small contribution to the heritability of the disease. The aim of this study is to improve the estimate of the CD risk in siblings, by adding to HLA a small set of non-HLA genes. One-hundred fifty-seven Italian families...

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Identifiers

PMID: 22087237
DOI: 10.1371/journal.pone.0026920
PMCID: PMC3210127

Genes

LPP
REL
RGS1
CCR1
CCR3
OLIG3
SCHIP1
TAGAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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