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Article

Genetic contribution of the HLA region to the familial clustering of coeliac disease

1 Jul 1997

Abstract excerpt

In order to assess the effect of the HLA region on familiality of coeliac disease (CD), we carried out a study on 121 CD index cases and 325 first degree relatives. The transmission disequilibrium test confirmed the importance of the HLA-DR3 haplotype in CD susceptibility. However, the different distortion found in affected children inheriting maternal or paternal DR3 alleles suggested that the sex of the parent...

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Identifiers

PMID: 9365784
DOI: 10.1046/j.1469-1809.1997.6140307.x

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