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Article

Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes.

Genes and immunity - 1 Apr 2010

Valdes A M, Thomson G, Barcellos L F

Abstract excerpt

Human leukocyte antigen (HLA) class II DRB1 and DQB1 represent the major type I diabetes (T1D) genetic susceptibility loci; however, other genes in the HLA region are also involved in T1D risk. We analyzed 1411 pedigrees (2865 affected individuals) from the type I diabetes genetics consortium genotyped for HLA classical loci and for 12 single-nucleotide polymorphisms (SNPs) in the class III region previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20054343
DOI: 10.1038/gene.2009.104
PMCID: PMC2858242

Genes

CFB
LTA

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Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes.PMID 20054343Read ↗

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