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Article

Regulation of aging and age-related disease by DAF-16 and heat-shock factor.

Science (New York, N.Y.) - 16 May 2003

Hsu Ao-Lin, Murphy Coleen T, Kenyon Cynthia

Abstract excerpt

The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is...

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Forkhead Transcription Factors
Gene Expression Regulation
Heat-Shock Response
Insulin
Longevity
Mutation
Receptor, IGF Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Insulin

Transcription Factors

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Identifiers

PMID: 12750521
DOI: 10.1126/science.1083701

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