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Article

Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2006

Singh Varsha, Aballay Alejandro

Abstract excerpt

Innate immunity comprises physical barriers, pattern-recognition receptors, antimicrobial substances, phagocytosis, and fever. Here we report that increased temperature results in the activation of a conserved pathway involving the heat-shock (HS) transcription factor (HSF)-1 that enhances immunity in the invertebrate Caenorhabditis elegans. The HSF-1 defense response is independent of the p38 MAPK/PMK-1 pathway...

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Identifiers

PMID: 16916933
DOI: 10.1073/pnas.0604050103
PMCID: PMC1559758

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