Article
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
Molecular biology of the cell - 1 Feb 2004
Morley James F, Morimoto Richard I
Abstract excerpt
The correlation between longevity and stress resistance observed in long-lived mutant animals suggests that the ability to sense and respond to environmental challenges could be important for the regulation of life span. We therefore examined the role of heat shock factor (HSF-1), a master transcriptional regulator of stress-inducible gene expression and protein folding homeostasis, in the regulation of...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Heat-Shock Proteins
- Longevity
- Molecular Chaperones
- Mutation
- Nervous System
- RNA Interference
- Transcription Factors