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Article

Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.

Genetics - 1 Jul 2002

Garigan Delia, Hsu Ao-Lin, Fraser Andrew G, Kamath Ravi S, Ahringer Julie, Kenyon Cynthia

Abstract excerpt

The genetic analysis of life span has revealed many interesting genes and pathways; however, our understanding of aging has been limited by the lack of a way to assay the aging process itself. Here we show that the tissues of aging worms have a characteristic appearance that is easy to recognize and quantify using Nomarski optics. We have used this assay to determine whether life-span mutations affect the rate of...

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Identifiers

PMID: 12136014
DOI: 10.1093/genetics/161.3.1101
PMCID: PMC1462187

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Source receipt: pubmed, retrieved 7 Sept 2026.

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