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Article

β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development.

The EMBO journal - 6 Oct 2010

Tipping Marla, Kim Yoosik, Kyriakakis Phillip, Tong Mei, Shvartsman Stanislav Y, Veraksa Alexey

Abstract excerpt

β-Arrestins have been implicated in the regulation of multiple signalling pathways. However, their role in organism development is not well understood. In this study, we report a new in vivo function of the Drosophila β-arrestin Kurtz (Krz) in the regulation of two distinct developmental signalling modules: MAPK ERK and NF-κB, which transmit signals from the activated receptor tyrosine kinases (RTKs) and the Toll...

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Identifiers

PMID: 20802461
DOI: 10.1038/emboj.2010.202
PMCID: PMC2957207

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