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Article

Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway.

G3 (Bethesda, Md.) - 2 Mar 2018

Johns Alex R, Henstridge Michelle A, Saligari Melissa J, Moore Karyn A, Whisstock James C, Warr Coral G, Johnson Travis K

Abstract excerpt

Patterning of the Drosophila embryonic termini by the Torso (Tor) receptor pathway has long served as a valuable paradigm for understanding how receptor tyrosine kinase signaling is controlled. However, the mechanisms that underpin the control of Tor signaling remain to be fully understood. In particular, it is unclear how the Perforin-like protein Torso-like (Tsl) localizes Tor activity to the embryonic termini....

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Identifiers

PMID: 29363515
DOI: 10.1534/g3.117.300491
PMCID: PMC5844297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genome-Wide Screen for New Components of the Drosophila melanogaster Torso Receptor Tyrosine Kinase Pathway.PMID 29363515Read ↗

Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling.Semantic proximity Read ↗

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis.Semantic proximity Read ↗

Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo.Semantic proximity Read ↗

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing.Semantic proximity Read ↗

torso-like encodes the localized determinant of Drosophila terminal pattern formation.Semantic proximity Read ↗

Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo.Semantic proximity Read ↗

Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila.Semantic proximity Read ↗

Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein.Semantic proximity Read ↗

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.Semantic proximity Read ↗

GCL pruning of PIP3 establishes the soma-germline boundarySemantic proximity Read ↗

The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila.Semantic proximity Read ↗

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