Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.

The Journal of biological chemistry - 25 Jul 2003

Hong Yu Holly, Varanasi Usha S, Yang Wenbo, Leff Todd

Abstract excerpt

AMP-activated protein kinase (AMPK) is the central component of a cellular signaling system that regulates multiple metabolic enzymes and pathways in response to reduced intracellular energy levels. The transcription factor hepatic nuclear factor 4alpha (HNF4alpha) is an orphan nuclear receptor that regulates the expression of genes involved in energy metabolism in the liver, intestine, and endocrine pancreas....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Gene Expression Regulation, Enzymologic

Share to Hepatocyte Nuclear Factor 4

Share to Multienzyme Complexes

Share to Phosphoproteins

Share to Serine

Source

Identifiers

PMID: 12740371
DOI: 10.1074/jbc.M304112200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.PMID 12740371Read ↗

Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.Semantic proximity Read ↗

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and DiseaseSemantic proximity Read ↗

Investigating the regulation of AMP-activated protein kinase and SNF1Semantic proximity Read ↗

Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation.Semantic proximity Read ↗

AMPK: An Epigenetic Landscape ModulatorSemantic proximity Read ↗

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.Semantic proximity Read ↗

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read ↗

Multiple post-translational modifications in hepatocyte nuclear factor 4α.Semantic proximity Read ↗

Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.Semantic proximity Read ↗

Characterization of the Human PPARα Promoter: Identification of a Functional Nuclear Receptor Response ElementSemantic proximity Read ↗

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue.Semantic proximity Read ↗

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.