ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

Abstract excerpt

As transcriptional factors, nuclear receptors (NRs) function as major regulators of gene expression. In particular, dysregulation of NR activity has been shown to significantly alter metabolic homeostasis in various contexts leading to metabolic disorders and cancers. The orphan estrogen-related receptor (ERR) subfamily of NRs, comprised of ERRα, ERR, and ERR, for which a natural ligand has yet to be...

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