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Article

Multiple post-translational modifications in hepatocyte nuclear factor 4α.

Biochemical and biophysical research communications - 15 Jul 2011

Yokoyama Atsushi, Katsura Shogo, Ito Ryo, Hashiba Waka, Sekine Hiroki, Fujiki Ryoji, Kato Shigeaki

Abstract excerpt

To investigate the role of post-translational modifications (PTMs) in the hepatocyte nuclear factor 4α (HNF4α)-mediated transcription, we took a comprehensive survey of PTMs in HNF4α protein by mass-spectrometry and identified totally 8 PTM sites including newly identified ubiquitilation and acetylation sites. To assess the impact of identified PTMs in HNF4α-function, we introduced point mutations at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21708125
DOI: 10.1016/j.bbrc.2011.06.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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