Article
Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation.
Biochimica et biophysica acta - 1 Jul 2014
Zhao Long, Chen Hui, Zhan Yi-Qun, Li Chang-Yan, Ge Chang-Hui, Zhang Jian-Hong, Wang Xiao-Hui, Yu Miao, Yang Xiao-Ming
Abstract excerpt
Hepatocyte nuclear factor-1 alpha (HNF1α) exerts important effects on gene expression in multiple tissues. Several studies have directly or indirectly supported the role of phosphorylation processes in the activity of HNF1α. However, the molecular mechanism of this phosphorylation remains largely unknown. Using microcapillary liquid chromatography MS/MS and biochemical assays, we identified a novel...
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