Article
Exo1: a new chemical inhibitor of the exocytic pathway.
Proceedings of the National Academy of Sciences of the United States of America - 27 May 2003
Feng Yan, Yu Sidney, Lasell Troy K R, Jadhav Ashutosh P, Macia Eric, Chardin Pierre, Melancon Paul, Roth Michael, Mitchison Timothy, Kirchhausen Tomas
Abstract excerpt
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus acutely inhibiting the traffic emanating from the endoplasmic reticulum. Like Brefeldin A (BFA), Exo1 induces the rapid release of...
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