Article
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2007
Viaud Julien, Zeghouf Mahel, Barelli Hélène, Zeeh Jean-Christophe, Padilla André, Guibert Bernard, Chardin Pierre, Royer Catherine A, Cherfils Jacqueline, Chavanieu Alain
Abstract excerpt
Small molecules that produce nonfunctional protein-protein complexes are an alternative to competitive inhibitors for the inhibition of protein functions. Here we target the activation of the small GTP-binding protein Arf1, a major regulator of membrane traffic, by the Sec7 catalytic domain of its guanine nucleotide exchange factor ARNO. The crystal structure of the Arf1-GDP/ARNO complex, which initiates the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.