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Article

An Arf1 GTPase mutant with different responses to GEF inhibitors.

Biochemical and biophysical research communications - 5 Dec 2008

Flisiak Sebastian, Zeeh Jean-Christophe, Guibert Bernard, Cherfils Jacqueline, Zeghouf Mahel

Abstract excerpt

Guanine nucleotide exchange factors (GEFs) stimulate the activation of small GTP-binding proteins (GTPases). Establishing their specificity is a challenging issue, in which chemical genetics are rapidly gaining interest. We report a mutation in the Arf1 GTPase, K38A, which differentially alters its sensitivity to GEF inhibitors. The mutation renders Arf1 insensitive to LM11, a GEF inhibitor that we previously...

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PMID: 18834864
DOI: 10.1016/j.bbrc.2008.09.107

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