Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1.

The Journal of biological chemistry - 11 Jul 2003

Fitch Michael J, Donato Justin J, Tye Bik K

Abstract excerpt

The Saccharomyces cerevisiae Mcm7 protein is a subunit of the presumed heteromeric MCM helicase that melts origin DNA and unwinds replication forks. Previous work showed that Mcm1 binds constitutively to the MCM7 promoter and regulates MCM7 expression. Here, we identify Mcm7 as a novel cofactor of Mcm1 in the regulation of MCM7 expression. Transcription of MCM7 is increased in the mcm7-1 mutant and decreased in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Polyomavirus Transforming
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Linking Reagents

Share to Deoxyribonuclease I

Share to Formaldehyde

Share to Mitosis

Share to Precipitin Tests

Source

Identifiers

PMID: 12738768
DOI: 10.1074/jbc.M300699200

Genes

MCM7
CDC6
MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1.PMID 12738768Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Semantic proximity Read ↗

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.Semantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activationSemantic proximity Read ↗

Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.Semantic proximity Read ↗

Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humansSemantic proximity Read ↗

The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription.Semantic proximity Read ↗

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.Semantic proximity Read ↗

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.