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Article

Thrombocytopathy leading to impaired in vivo haemostasis and thrombosis in platelet type von Willebrand disease.

Thrombosis and haemostasis - 28 Feb 2017

Kaur Harmanpreet, Corscadden Kathryn, Ware Jerry, Othman Maha

Abstract excerpt

Platelet defects due to hyper-responsive GPIbα causing enhanced VWF interaction, counter-intuitively result in bleeding rather than thrombosis. The historical explanation of platelet/VWF clearance fails to explain mechanisms of impaired haemostasis particularly in light of reported poor platelet binding to fibrinogen. This study aimed to evaluate the defects of platelets with hyper-responsive GPIbα and their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28004055
DOI: 10.1160/TH16-04-0317

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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