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Article

Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis.

Blood - 11 Dec 2014

Chen Jianchung, Zhou Hairu, Diacovo Alexander, Zheng X Long, Emsley Jonas, Diacovo Thomas G

Abstract excerpt

Platelet-von Willebrand factor (VWF) interactions must be tightly regulated in order to promote effective hemostasis and prevent occlusive thrombus formation. However, it is unclear what role the inherent properties of the bond formed between the platelet receptor glycoprotein Ibα and the A1 domain of VWF play in these processes. Using VWF-A1 knock-in mice with mutations that enhance (I1309V) or disrupt (R1326H)...

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Source

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Identifiers

PMID: 25293780
DOI: 10.1182/blood-2014-04-569392
PMCID: PMC4263987

Genes

VWF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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