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Article

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.

Blood - 28 Oct 2010

Bender Markus, Hofmann Sebastian, Stegner David, Chalaris Athena, Bösl Michael, Braun Attila, Scheller Jürgen, Rose-John Stefan, Nieswandt Bernhard

Abstract excerpt

Glycoprotein VI (GPVI) mediates platelet activation on exposed subendothelial collagens at sites of vascular injury and thereby contributes to normal hemostasis, but also to the occlusion of diseased vessels in the setting of myocardial infarction or stroke. GPVI is an attractive target for antithrombotic therapy, particularly because previous studies have shown that anti-GPVI antibodies induce irreversible...

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Identifiers

PMID: 20644114
DOI: 10.1182/blood-2010-06-289108

Genes

ADAM10
ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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