Article
The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
Developmental cell - 1 May 2003
Doronkin Sergey, Djagaeva Inna, Beckendorf Steven K
Abstract excerpt
The COP9 signalosome (CSN) is an eight-subunit complex that regulates multiple signaling and cell cycle pathways. Here we link the CSN to the degradation of Cyclin E, which promotes the G1-S transition in the cell cycle and then is rapidly degraded by the ubiquitin-proteasome pathway. Using CSN4 and CSN5/Jab1 mutants, we show that the CSN acts during Drosophila oogenesis to remove Nedd8 from Cullin1, a subunit of...
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