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Article

The cyclin-dependent kinase inhibitor Roughex is involved in mitotic exit in Drosophila.

Current biology : CB - 6 Feb 2001

Foley E, Sprenger F

Abstract excerpt

BACKGROUND: Exit from mitosis is a tightly regulated event. This process has been studied in greatest detail in budding yeast, where several activities have been identified that cooperate to downregulate activity of the cyclin-dependent kinase (CDK) Cdc28 and force an exit from mitosis. Cdc28 is inactivated through proteolysis of B-type cyclins by the multisubunit ubiquitin ligase termed the anaphase promoting...

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PMID: 11231149
DOI: 10.1016/s0960-9822(01)00050-1

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