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Article

Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2008

Oren-Giladi Pazit, Krieger Ofra, Edgar Bruce A, Chamovitz Daniel A, Segal Daniel

Abstract excerpt

The COP9 signalosome (CSN) is a multisubunit regulator highly conserved in evolution. We show here that CSN subunit 8 (CSN8) is essential for Drosophila development. CSN8 is maternally contributed and present throughout development. Null mutants generated in this study are larval lethal, showing phenotypes associated with mutations in either CSN4 (molting defects) or CSN5 (melanotic tumors). Analysis of mitotic...

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Identifiers

PMID: 18298797
DOI: 10.1111/j.1365-2443.2008.01164.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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