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Article

Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression.

Molecular systems biology - 1 Jan 2007

Oron Efrat, Tuller Tamir, Li Ling, Rozovsky Nina, Yekutieli Daniel, Rencus-Lazar Sigal, Segal Daniel, Chor Benny, Edgar Bruce A, Chamovitz Daniel A

Abstract excerpt

The COP9 signalosome (CSN), an eight-subunit protein complex, is conserved in all higher eukaryotes. CSN intersects the ubiquitin-proteasome pathway, modulating signaling pathways controlling various aspects of development. We are using Drosophila as a model system to elucidate the function of this important complex. Transcriptome data were generated for four csn mutants, sampled at three developmental time...

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PMID: 17486136
DOI: 10.1038/msb4100150
PMCID: PMC2673709

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Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression.PMID 17486136Read ↗

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