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Article

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

Science (New York, N.Y.) - 18 May 2001

Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf D A, Wei N, Shevchenko A, Deshaies R J

Abstract excerpt

SCF ubiquitin ligases control various processes by marking regulatory proteins for ubiquitin-dependent proteolysis. To illuminate how SCF complexes are regulated, we sought proteins that interact with the human SCF component CUL1. The COP9 signalosome (CSN), a suppressor of plant photomorphogenesis, associated with multiple cullins and promoted cleavage of the ubiquitin-like protein NEDD8 from Schizosaccharomyces...

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Source

Identifiers

PMID: 11337588
DOI: 10.1126/science.1059780

Genes

CUL1
NEDD8
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.PMID 11337588Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

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Conservation of the COP9/signalosome in budding yeast.Semantic proximity Read ↗

CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome.Semantic proximity Read ↗

Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development.Semantic proximity Read ↗

The Emerging Role of the COP9 Signalosome in CancerSemantic proximity Read ↗

Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes.Semantic proximity Read ↗

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F-box-directed CRL complex assembly and regulation by the CSN and CAND1.Semantic proximity Read ↗

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