Article
A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.
Atherosclerosis - 1 May 2003
Elrayess Mohamed A, Webb Karen E, Flavell David M, Syvänne Mikko, Taskinen Marja-Riitta, Frick M Heikki, Nieminen Markku S, Kesäniemi Y Antero, Pasternack Amos, Jukema J Wouter, Kastelein John J P, Zwinderman Aeilko H, Humphries Steve E
Abstract excerpt
A 53G>A polymorphism identified in the 5' untranslated region (5'UTR) of the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene alters a putative shear stress responsive element (SSRE). PECAM-1 was shown to be responsive to shear stress and transient transfection of human umbilical vein endothelial cell (HUVECs) with two luciferase reporter constructs driven by the PECAM-1 promoter and 5'UTR showed a...
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