Article
Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future: A Serial Optical Coherence Tomography and Computational Fluid Dynamics Study.
Circulation. Cardiovascular interventions - 1 Aug 2017
Yamamoto Erika, Siasos Gerasimos, Zaromytidou Marina, Coskun Ahmet U, Xing Lei, Bryniarski Krzysztof, Zanchin Thomas, Sugiyama Tomoyo, Lee Hang, Stone Peter H, Jang Ik-Kyung
Abstract excerpt
BACKGROUND: Low endothelial shear stress (ESS) is associated with plaque progression and vulnerability. To date, changes in plaque phenotype over time in relation to ESS have not been studied in humans. The aim of this study was to investigate whether local ESS can predict subsequent changes to plaque phenotype using optical coherence tomography. METHODS AND RESULTS: A total of 25 coronary arteries from 20...
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