Article

Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells

2023-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Coronary artery disease (CAD) is one of the major causes of mortality worldwide. Recent genome-wide association studies have started to unravel the genetic architecture of the disease. Such efforts have identified Calcitonin receptor-like (CALCRL), an important mediator of the endothelial fluid shear stress response, associated with CAD risk variants. In this study we functionally characterized...

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Literature Corpus work: 73ec8cf4-3c3a-5600-a260-5e1e70378afc
DOI: 10.1101/2023.02.08.527795

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