PECAM-1 polymorphism affects monocyte adhesion to endothelial cells.

doi:10.1097/TP.0b013e3181622d65

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Article

PECAM-1 polymorphism affects monocyte adhesion to endothelial cells.

Transplantation - 15 Feb 2008

Goodman Reyna S, Kirton Christopher M, Oostingh Gertie J, Schön Michael P, Clark Michael R, Bradley J Andrew, Taylor Craig J

Abstract excerpt

BACKGROUND: Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) plays an important role in leukocyte-endothelial cell adhesion and transmigration. Single nucleotide polymorphisms of PECAM-1 encoding amino acid substitutions at positions 98 leucine/valine (L/V), 536 serine/asparagine (S/N), and 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR and VNG)....

Topics

Cell Adhesion
Cells, Cultured
Endothelial Cells
Genotype
Humans
Monocytes
Platelet Endothelial Cell Adhesion Molecule-1
Polymorphism, Genetic

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PMID: 18301339
DOI: 10.1097/TP.0b013e3181622d65

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