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Article

Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease.

Circulation research - 15 Oct 2004

Cattaruzza Marco, Guzik Tomasz J, Słodowski Wojciech, Pelvan Ayşegül, Becker Jürgen, Halle Martin, Buchwald Arnd B, Channon Keith M, Hecker Markus

Abstract excerpt

Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant...

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Identifiers

PMID: 15375006
DOI: 10.1161/01.RES.0000145359.47708.2f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15375006-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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