Article
AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2016
Shentu Tzu-Pin, He Ming, Sun Xiaoli, Zhang Jianlin, Zhang Fan, Gongol Brendan, Marin Traci L, Zhang Jiao, Wen Liang, Wang Yinsheng, Geary Gregory G, Zhu Yi, Johnson David A, Shyy John Y-J
Abstract excerpt
OBJECTIVE: Cortactin translocates to the cell periphery in vascular endothelial cells (ECs) on cortical-actin assembly in response to pulsatile shear stress. Because cortactin has putative sites for AMP-activated protein kinase (AMPK) phosphorylation and sirtuin 1 (SIRT1) deacetylation, we examined the hypothesis that AMPK and SIRT1 coregulate cortactin dynamics in response to shear stress. APPROACH AND RESULTS:...
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