Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.

doi:10.1161/ATVBAHA.123.318964

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Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2024

Selvarajan Ilakya, Kiema Miika, Huang Ru-Ting, Li Jin, Zhu Jiayu, Pölönen Petri, Örd Tiit, Õunap Kadri, Godiwala Mehvash, Golebiewski Anna Kathryn, Ravindran Aarthi, Mäklin Kiira, Toropainen Anu, Stolze Lindsey K, Arce Maximiliano, Magnusson Peetra U, White Stephen, Romanoski Casey E, Heinäniemi Merja, Laakkonen Johanna P, Fang Yun, Kaikkonen Minna U

Abstract excerpt

BACKGROUND: CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease. In this study, we functionally characterized the noncoding regulatory elements carrying coronary artery disease that risks single-nucleotide polymorphisms and studied their role in the regulation of CALCRL expression in...

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PMID: 38602103
DOI: 10.1161/ATVBAHA.123.318964
PMCID: PMC11111333

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