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Article

Pancreatic beta-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2011

Kavaler Sarah, Morinaga Hidetaka, Jih Alice, Fan WuQiang, Hedlund Maria, Varki Ajit, Kim Jane J

Abstract excerpt

Type 2 diabetes is highly prevalent in human populations, particularly in obese individuals, and is characterized by progressive pancreatic β-cell dysfunction and insulin resistance. Most mammals, including Old World primates, express two major kinds of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), typically found at the distal ends of glycoconjugate chains at the cell...

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Identifiers

PMID: 21350118
DOI: 10.1096/fj.10-175281
PMCID: PMC3101031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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