Article
Genomic mutations with amino acid substitutions of circulating hepatitis B virus found in non-B, non-C patients with hepatocellular carcinoma.
Internal medicine (Tokyo, Japan) - 1 Apr 2003
Nakamoto Nobuhiro, Saito Hidetsugu, Ebinuma Hirotoshi, Tada Shinichiro, Saito Yoshimasa, Kurita Satoshi, Kitamura Kumi, Ishii Hiromasa
Abstract excerpt
OBJECTIVE: Most hepatocellular carcinoma (HCC) in Japan is caused by chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV). HBV DNA has been detected in the serum and liver tissue of some proportion of those patients who are HBs antigen-negative and HCV antibody-negative; i.e., non-B, non-C (NBNC) patients with HCC. We sought to detect HBV DNA in the serum from NBNC HCC cases and to...
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