Article
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Microbial pathogenesis - 1 Aug 2017
Jiao Fengping, Long Lu, Ding Shanlong, Xie Xiaomeng, Jia Le, Lu Fengmin
Abstract excerpt
BACKGROUND: More than half of hepatocellular carcinomas (HCCs) are etiologically attributed to hepatitis B virus (HBV) infection, but it remains unclear whether HBV mutations are virological factors that contribute to formation of HCC or instead reflect accumulation during the progression of HBV-...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- DNA, Circular
- DNA, Viral
- Female
- Hep G2 Cells
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Prognosis
- Virus Replication