Article
Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers.
Gastroenterology - 1 Sept 1996
Minami M, Poussin K, Kew M, Okanoue T, Bréchot C, Paterlini P
Abstract excerpt
BACKGROUND & AIMS: Hepatitis B virus genomes have been detected in hepatocellular carcinoma developed without the pretumoral step of cirrhosis; this finding is consistent with a direct effect of the virus in liver cell transformation. The aim of this study was to investigate the molecular bases f...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Hepatocellular
- DNA, Viral
- DNA-Directed RNA Polymerases
- Genotype
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Middle Aged
- Molecular Sequence Data
- Mutation
- Signal Transduction
- Viral Core Proteins