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Article

Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates.

Archives of virology - 1 Jan 1998

Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S

Abstract excerpt

We determined full-length nucleotide sequence of hepatitis B virus (HBV) genome in sera from 40 Japanese patients with HBsAg-positive hepatocellular carcinoma (HCC), in order to obtain information on HCC-specific characteristics, if any, of the HBV genome. Direct sequencing of the long distance PCR products starting from 50 microliters of serum samples revealed that 95% of our isolates were of genotype C, and...

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PMID: 9930189
DOI: 10.1007/s007050050463

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