Article
Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease.
Neuroscience letters - 15 May 2003
Depboylu Candan, Du Yansheng, Müller Ulrich, Kurz Alexander, Zimmer Reinhilde, Riemenschneider Matthias, Gasser Thomas, Oertel Wolfgang H, Klockgether Thomas, Dodel Richard C, Oertelf Wolfgang H
Abstract excerpt
There is increasing evidence that immune mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recently, polymorphisms of the interleukin (IL)-1 and IL-6 genes were found to be associated with late-onset AD. The immunoregulatory IL-10 downregulates synthesis of pro-inflammatory cytokines such as IL-1. Current evidence suggests that some polymorphisms in the IL-10 promoter may have functional...
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