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Article

Lack of association between IL-10 and IL-18 gene promoter polymorphisms and Parkinson's disease with cognitive impairment in a Chinese population.

Scientific reports - 2 Feb 2016

Liu Zhenhua, Guo Jifeng, Wang Yaqin, Li Kai, Kang Jifeng, Wei Yang, Sun Qiying, Xu Qian, Xu Changshui, Yan Xinxiang, Tang Beisha

Abstract excerpt

Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleotide polymorphisms (SNPs) in the IL-10 promoter (rs1800871 and rs1800872) and in the IL-18...

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PMID: 26830320
DOI: 10.1038/srep19021
PMCID: PMC4735643

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