Article
Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.
The EMBO journal - 1 Dec 1992
Garzino V, Pereira A, Laurenti P, Graba Y, Levis R W, Le Parco Y, Pradel J
Abstract excerpt
Variegation in Drosophila is a manifest illustration of the important role played by chromatin structure in gene expression. We have isolated mutants of modulo (mod) and shown that this gene is a dominant suppressor of variegation. Null mutants are recessive lethal with a melanotic tumour phenotype. The mod protein directly binds DNA, which indicates that it may serve to anchor multimeric complexes promoting...
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