Article
Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.
The EMBO journal - 1 Dec 1992
Garzino V, Pereira A, Laurenti P, Graba Y, Levis R W, Le Parco Y, Pradel J
Abstract excerpt
Variegation in Drosophila is a manifest illustration of the important role played by chromatin structure in gene expression. We have isolated mutants of modulo (mod) and shown that this gene is a dominant suppressor of variegation. Null mutants are recessive lethal with a melanotic tumour phenoty...
Topics
- Animals
- Blotting, Southern
- Blotting, Western
- DNA
- DNA-Binding Proteins
- Drosophila
- Fluorescent Antibody Technique
- Gene Expression Regulation
- Genes, Dominant
- Genes, Lethal
- Genes, Recessive
- Immunohistochemistry
- Larva
- Microscopy, Electron, Scanning
- Mutation
- Pigmentation