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Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

18 Jun 2015

Abstract excerpt

BACKGROUND: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Nine percent of Caucasians lack or have very low OCT1 activity due to loss-of-function polymorphisms in OCT1 gene. Here we analyzed the global genetic variability in OCT1 to estimate the therapeutic relevance of OCT1 polymorphisms in populations beyond Caucasians and to...

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PMID: 26157489
DOI: 10.1186/s13073-015-0172-0

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