Article
Genetic dissection of anxiety in autoimmune disease.
Human molecular genetics - 15 May 2003
Nakamura Kazuhiro, Xiu Yan, Ohtsuji Mareki, Sugita Gen, Abe Masaaki, Ohtsuji Naomi, Hamano Yoshitomo, Jiang Yi, Takahashi Noriko, Shirai Toshikazu, Nishimura Hiroyuki, Hirose Sachiko
Abstract excerpt
Systemic lupus erythematosus (SLE), a complex multigenic disease, is characterized by hypergammaglobulinemia, autoantibody production and immune complex-type lupus nephritis. In addition to these signs and symptoms in SLE, there can be symptoms of neurological disorders, including anxiety. To clarify mechanisms governing the anxiety seen in lupus, we carried out genome-wide scans, and found that the region...
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