Article
Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1999
Dahlman I, Jacobsson L, Glaser A, Lorentzen J C, Andersson M, Luthman H, Olsson T
Abstract excerpt
The immunization of inbred Dark Agouti (DA) rats with an emulsion containing homogenized spinal cord and CFA induces chronic relapsing experimental autoimmune encephalomyelitis (EAE), a disease with many similarities to multiple sclerosis. We report here the first genome-wide search for quantitative trait loci regulating EAE in the rat using this model. We identified one quantitative trait locus on chromosome 9,...
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