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Article

Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.

Molecular cell - 1 Apr 2003

Kwak Youn Tae, Guo Jun, Prajapati Shashi, Park Kyu-Jin, Surabhi Rama M, Miller Brady, Gehrig Peter, Gaynor Richard B

Abstract excerpt

SPT5 and its binding partner SPT4 function in both positively and negatively regulating transcriptional elongation. The demonstration that SPT5 and RNA polymerase II are targets for phosphorylation by CDK9/cyclin T1 indicates that posttranslational modifications of these factors are important in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12718890
DOI: 10.1016/s1097-2765(03)00101-1

Genes

CDK9
PRMT1
PRMT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12718890-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.PMID 12718890Read ↗

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SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.Semantic proximity Read ↗

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RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing.Semantic proximity Read ↗

Tripartite phosphorylation of SPT5 by CDK9 times pause release and tunes elongation rate of RNA polymerase II.Semantic proximity Read ↗

The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II.Semantic proximity Read ↗

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