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Article

Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.

Nucleic acids research - 16 Nov 2015

Mbogning Jean, Pagé Viviane, Burston Jillian, Schwenger Emily, Fisher Robert P, Schwer Beate, Shuman Stewart, Tanny Jason C

Abstract excerpt

Transcription by RNA polymerase II (RNAPII) is accompanied by a conserved pattern of histone modifications that plays important roles in regulating gene expression. The establishment of this pattern requires phosphorylation of both Rpb1 (the largest RNAPII subunit) and the elongation factor Spt5 on their respective C-terminal domains (CTDs). Here we interrogated the roles of individual Rpb1 and Spt5 CTD...

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Identifiers

PMID: 26275777
DOI: 10.1093/nar/gkv837
PMCID: PMC4787787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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