Article
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.
Genes & development - 1 Feb 1998
Hartzog G A, Wada T, Handa H, Winston F
Abstract excerpt
Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as transcription factors that modify chromatin structure. In this work, we report new genetic and biochemical studies of Spt4, Spt5, and Spt6 that reveal a role for these factors in transcription elongation. We have isolated conditional mutations in SPT5 that can be suppressed in an...
Topics
- Amino Acid Sequence
- Chromosomal Proteins, Non-Histone
- Cold Temperature
- Fungal Proteins
- Genes, Fungal
- Genes, Suppressor
- Histone Chaperones
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Protein Binding
- RNA Polymerase II
- Saccharomyces cerevisiae