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Article

PRMT5 Facilitates Infectious Bursal Disease Virus Replication through Arginine Methylation of VP1.

Journal of virology - 30 Mar 2023

Hu Xifeng, Chen Zheng, Wu Xiangdong, Fu Qiuling, Chen Zhen, Huang Yu, Wu Huansheng

Abstract excerpt

The infectious bursal diseases virus (IBDV) polymerase, VP1 protein, is responsible for transcription, initial translation and viral genomic replication. Knowledge about the new kind of post-translational modification of VP1 supports identification of novel drugs against the virus. Because the arginine residue is known to be methylated by protein arginine methyltransferase (PRMT) enzyme, we investigated whether...

Topics

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Cell Line
Chickens
Infectious bursal disease virus
Methylation
Protein-Arginine N-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Processing, Post-Translational

Viral Structural Proteins

Virus Replication

Source

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Identifiers

PMID: 36786602
DOI: 10.1128/jvi.01637-22
PMCID: PMC10062139

Genes

PRMT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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