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Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

22 May 2008

Abstract excerpt

BACKGROUND: The rate of transcription of the HIV-1 viral genome is mediated by the interaction of the viral protein Tat with the LTR and other transcriptional machinery. These specific interactions can be affected by the state of post-translational modifications on Tat. Previously, we have shown that Tat can be phosphorylated and acetylated in vivo resulting in an increase in the rate of transcription. In the...

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PMID: 18498648
DOI: 10.1186/1742-4690-5-40

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